Pharmaceutics-1, |easy notes|

  The ingredients employed in suspensions vary as per the nature of the drug, ie diffusible or indiffusible. Suspensions containing indiffusible solids require thickening agents Suspensions for internal use are mostly aqueous, whereas, for other routes it may be aqueous non-aqueous, hydroalcoholic or oily. Drug-  The drug should have minimum solubility, maximum chemical stability and good wettability in the vehicle. Drugs with some solubility in the vehicle, could result in the growth of crystals due to fluctuations in storage temperatures. Preparation of suspensions in pharmaceutics containing diffusible solids is less complex than that of the Those with indiffusible solids. Incorporation of suspending agent latter type may lead to problems such as, adsorption of flavours and preservatives, unpourability, etc. The drug particles are also generated by chemical reaction or by precipitation eg Blight milk of magnesia. The precipitation is done either by change in solvent or the pH of s

  Biphasic liquid dosage form : SUSPENSION. What is Suspension? Credit:- Shutterstock.com -> Suspension are the mixtures containing insoluble solids. Suspension are heterogeneous, biphasic, thermodynamically unstable liquid items in which a solid particles are uniformly distributed in liquid phase (dispersion medium). ☆Classification of Suspension:- • Particle size- Colloidal & Coarse.   • Density of solids - Diffusible & Indiffusible.   • Arrangement of suspended phase - Focculated & Defocculated • Route of administration - Internal & External. 1) Colloidal suspensions: When the solid particles are less than 1um in size, suspensions are called colloidal suspensions. 2) Coarse suspensions: When the size of solid particles is from 1um to 50-75 um, these suspensions are termed as coarse suspensions. 3) Suspensions containing diffusible solids: Many of the drug substances are light in weight and possess good wetting properties. After shaking, such drugs re

  •Mixtures are liquid preparations intended for oral administration and composed dissolved or dispersed drug. Definition ~  Pharmaceutical monophasic liquids (Solutions) are single phase liquid preparation composed of one or more pharmaceutically active ingredients dissolved in a solvent, that are intended to be used internally or externally.  Solutions for internal use are either aques or hydroalcoholic, whereas, solutions for external use are aqueous or non-aqueous According to the route of administration, pharmaceutical solutions are of the following type Advantages of Monophasic Liquids 1) Bioavailability of dissolved drug is rapid as compared to its insoluble form The dosage toms can be ranked in increasing order of bioavailability in the following order Capsules < Powders < Suspensions < Solutions. 2) The drug is more uniformly distributed in liquid vehide and provides high dosage accuracy than biophysics liquid. 3) Liquid preparations are easy to swallow and thus m