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COMMINUTION OF DRUGS •On a small scale, the pharmacist reduces the size of chemical substances by grinding with a mortar and pestle. •A finer grinding action is accomplished by using a mortar with a rough surface (as a porcelain mortar) than one with a smooth surface (as a glass mortar). •Grinding a drug in a mortar to reduce its particle size is termed trituration or comminution. Credit:- indianmart.com •On a large scale, various types of mills and pulverizers may be used to reduce particle size. • Through the grinding action of rapidly moving blades in the comminuting chamber, particles are reduced in size and passed through a screen of desired dimension to the collection container. The collection and containment system: ♧protects the environment from chemical dust ♧reduces product loss ♧prevents product contamination. Levigation •Levigation is commonly used in small scale preparation of ointments and suspensions to reduce the particle size and grittiness of the added pow
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